Inflammation is one of the underlying mechanisms in several chronic disease conditions like coronary artery disease, asthma, Alzheimer’s, arthritis and some cancers. In the present study the formulation chosen is a classical polyherbal preparation (Rasnadi Guggul) containing ingredients of plant and mineral origin. The study involved the pharmacological validation. The pharmacological evaluation involved acute models i.e. Carrageenan induced rat paw edema. In the Carrageenan induced rat paw edema model, the 250 mg/kg dose of the formulation showed significant activity (P<0.001) at the end of fifth and fourth hour respectively. Prolonged effects of the formulation were studied using cotton pellet granuloma. The efficacy of the formulation in the cotton pellet granuloma model was comparable to that of the positive control (P<0.001). Thus, it can be concluded that this preparation showed significant anti-inflammatory activity.
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